HBO Go now available on Roku boxes, HBO subscription still required to take advantage

Not a bad turnaround time, we have to say. Nary a month after revealing that HBO Go streaming would soon be pushed to Roku boxes around the known universe... HBO Go streaming has been pushed to Roku boxes around the known universe. As of now, Roku addicts can tap into unlimited access to over 1,400 HBO programs (that's movies, original series, sports, comedy, etc.), with one mondo stipulation: you have to be an HBO subscriber via some pay-TV company. Of course, HBO Go can also be accessed via your laptop, and you've probably got some form of HBO on-demand already, but look -- this is better. This is comprehensive. Use it, and don't ask questions. Capiche?

HBO Go now available on Roku boxes, HBO subscription still required to take advantage originally appeared on Engadget on Fri, 04 Nov 2011 16:49:00 EDT. Please see our terms for use of feeds.

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Girls Gone Gadgets 01: Premiere [NSFW-L]

Our podcast feed: Audio | Video Download Directly: Audio | Video Subscribe in iTunes: Audio | Video Georgia and Ashley Esqueda talk Android Xoom 2, geek dating dos and don’ts, how to rock (and not rock) your BlackBerry, advice for celebrity sexters, iHelicopters and Whale Trail for...

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Protein causes varicose veins

Friday, November 4, 2011

Varicose veins, sometimes referred to as "varices" in medical jargon, are usually just a cosmetic problem if they occur as spider veins. In their advanced stage, however, they pose a real health threat. In people with this widespread disorder, the blood is no longer transported to the heart unhindered but instead pools in the veins of the leg. This is because the vessel walls or venous valves no longer function adequately. Dr. Thomas Korff and his group at the Division of Cardiovascular Physiology (Director: Prof. Markus Hecker) of Heidelberg University's Institute of Physiology and Pathophysiology have now shown that the pathological remodeling processes causing varicose veins are mediated by a single protein.

As a response to increased stretching of the vessel wall, this protein triggers the production of several molecules promoting changes in wall architecture. The paper published in the current issue of FASEB Journal may offer a possibility for using drugs to decelerate the formation of or even prevent new varicose veins.

Previously, no suitable experimental systems existed for studying the way in which these changes in the cells of the blood vessels are controlled. For their studies, Korff and his team took advantage of the fact that blood vessels in the mouse ear are clearly visible and are also easily accessible for minor surgical procedures. In order to artificially set off processes that are similar to the formation of varicose veins, they tied off a vein with a thin thread. The elevated pressure in the vessels caused by the pooled blood led to the recognizable remodeling characteristic of varicose veins. In addition, in the affected veins, the cell proliferation rate and the production of MMP-2 increased. MMP-2 is an enzyme that breaks down the non-cellular components of the connective tissue of the blood vessels. On the other hand, there were no signs of an inflammatory response, which can be observed during other vessel remodeling processes.

Model allows agents to be tested

"Nevertheless, the cellular mechanisms that control the formation of varicose veins appear to be similar to mechanisms that orchestrate the remodeling of arteries in patients with high blood pressure," Korff explains. The transcription factor AP-1 which regulates the activity of certain genes and thus the corresponding protein production is regulated by the filling pressure in the blood vessels and in turn controls the formation of varicose veins, Korff adds. If AP-1 is inhibited, thus prohibiting it from activating genes, the characteristic corkscrew-like varicose veins do not form and cell proliferation and the production of enzymes that break down connective tissue remain at normal levels.

In a further experiment, the group showed that the results obtained in the mouse are also valid for humans. Varicose veins that have been surgically removed from patients exhibited the same cellular and molecular changes as the varicose veins created artificially in the mouse ear. Based on these results, Korff plans more studies. "Using our model, we can now more precisely analyze the early stages of the disorder and test possible drugs for their ability to prevent varicose vein formation, which, as a result, may improve the quality of life of afflicted patients."

According to the German Vascular League, 30 million people suffer from minor vein-related symptoms, whereby women are affected around twice as often as men. According to a health report published by the German government, 15 to 20 percent of the population has varicose veins.

###

University Hospital Heidelberg: http://www.klinikum.uni-heidelberg.de/

Thanks to University Hospital Heidelberg for this article.

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Cain struggles to overcome allegations controversy

FILE - In this Nov. 2, 2011 file photo, Republican presidential candidate Herman Cain arrives to speak on Capitol Hill in Washington. Cain is defending himself anew and _ without evidence _ blaming presidential rival Rick Perry's campaign of being behind the disclosure of years-old sexual harassment allegations against him. Cain is pressing forward, even as a third woman says she considered filing a complaint against him over sexually suggestive remarks and gestures. (AP Photo/Carolyn Kaster, File)

FILE - In this Nov. 2, 2011 file photo, Republican presidential candidate Herman Cain arrives to speak on Capitol Hill in Washington. Cain is defending himself anew and _ without evidence _ blaming presidential rival Rick Perry's campaign of being behind the disclosure of years-old sexual harassment allegations against him. Cain is pressing forward, even as a third woman says she considered filing a complaint against him over sexually suggestive remarks and gestures. (AP Photo/Carolyn Kaster, File)

Republican presidential candidate Herman Cain speaks at the Congressional Health Caucus Thought Leaders Series, Wednesday, Nov. 2, 2011, on Capitol Hill in Washington. (AP Photo/Carolyn Kaster)

Republican presidential candidate Herman Cain gestures as he speaks at the Congressional Health Caucus Thought Leaders Series, Wednesday, Nov. 2, 2011, on Capitol Hill in Washington. (AP Photo/Carolyn Kaster)

Republican presidential candidate Herman Cain wipes his brow as he speaks at the Congressional Health Caucus Thought Leaders Series, Wednesday, Nov. 2, 2011, on Capitol Hill in Washington. (AP Photo/Carolyn Kaster)

(AP) ? Republican presidential hopeful Herman Cain struggled to overcome the storm of controversy from sexual harassment accusations on Thursday as the threat of a damaging written statement by one of his accusers and shifting explanations by a top aide left his efforts and even his candidacy in doubt.

"This will not deter me" in the race for the White House, Cain declared, repeatedly denying the accusations in interviews on conservative media outlets.

"Did you tell a woman she looked good?" radio host Sean Hannity asked. "That dress looks hot?"

"Nope."

"Any flirtation that you can think of?"

"Nope," Cain said firmly.

At the same time, he and aides tried to demonstrate a campaign returning to normalcy or even benefiting from the controversy.

Cain held private meetings in New York during the day, including one on foreign policy with former Secretary of State Henry Kissinger.

And campaign spokesman J.D. Gordon said donors had sent in $1.2 million since news of the allegations first surfaced, far above the customary amount for several days.

Since it was reported late Sunday that at least two women had complained about Cain when they worked at the National Restaurant Association ? and had received financial settlements ? Cain has said consistently he never sexually harassed anyone. But his answers to other pertinent questions have changed. In one instance, he first denied knowing of any settlements with former employees, then said he recalled one, explaining he had been aware of an "agreement" but not a "settlement."

On Wednesday, Cain said he believed a political consultant for rival Rick Perry had leaked the information. The consultant, Curt Anderson, denied it.

In a television interview on Thursday with Fox News Channel, Mark Block, Cain's chief of staff, first stood by the accusation, then reversed course. "Until we get all the facts, I'm just going to say we accept what Mr. Anderson said."

It was unclear when all the facts might emerge.

Joel Bennett, an attorney for one of the women alleging sexual harassment, said he was seeking permission from the National Restaurant Association to release a statement on her behalf. Under an agreement stemming from her accusation in 1999, the woman agreed not to speak publicly about the episode she said occurred when she worked for the trade group and Cain was its president.

Asked whether he would like his former employer to agree to the request, Cain sidestepped.

"That's totally their decision," he said on Hannity's program. "I can't ask them to do that because that would create a legal liability that I don't want to be responsible for." Sue Hensley, a spokeswoman for the restaurant group, said its lawyers were reviewing the draft statement and would respond on Friday.

Cain specifically denied allegations by a third woman who told The Associated Press this week that she had considered filing a workplace complaint against him alleging aggressive and unwanted behavior, including a private invitation to his corporate apartment.

He also said his wife Gloria was "still 200 percent supportive of me in this whole race, 200 percent supportive of me as her husband, because I haven't done anything."

For the most part, Cain's presidential rivals steered clear of the controversy, preferring to let it play out.

The furor erupted at a time when Cain had vaulted to the top of public opinion polls as a leading conservative challenger to former Massachusetts Gov. Mitt Romney for the Republican nomination.

In one of his interviews during the day, Cain told the conservative Daily Caller it can be disorienting campaigning in the nation's capital.

"The way questions are asked, when I'm speaking to a group here in D.C. is coming from a totally different perspective than when I'm being asked questions from the real people. The real people come at it, here's the problem, what do you think the solution is?

"Inside D.C., inside the bubble as you call it, they're coming at the perspective of skepticism. ... You can't get it done. You're going to get knocked down. And you can just feel it in the way they ask the question and the way they respond."

Apart from seeking to burnish his credentials as a political outsider, Cain and his allies have also claimed that as a black conservative, he is subject to harshness because of his race. After listening to Hannity play recordings of vociferous critics, Cain said, "I'm a black conservative, and it is causing their heads to explode."

_____

Associated Press writers Steven Ohlemacher, Brett Blackledge and Laurie Kellman contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2011-11-03-Cain/id-8a9777f44a58465e87c36dd85ba6c51e

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Banks closed in Neb, Utah; 87 failures in 2011

(AP) ? Regulators on Friday closed a small bank in Nebraska and another in Utah, bringing to 87 the number of bank failures in the U.S. this year.

The number of closures has fallen sharply this year as banks have worked their way through the bad debt accumulated in the recession. By this time last year, regulators had shuttered 143 banks.

The Federal Deposit Insurance Corp. seized Mid City Bank, based in Omaha, Neb., with $106.1 million in assets and $105.5 million in deposits, and SunFirst Bank, based in Saint George, Utah, with $198.1 million in assets and $169.1 million in deposits. Purdum State Bank, based in Purdum, Neb., agreed to assume the assets and deposits of Mid City Bank. Cache Valley Bank, based in Logan, Utah, is acquiring the deposits and $177.3 million of the loans and other assets of SunFirst Bank.

In addition, the FDIC and Cache Valley Bank agreed to share losses on $128.9 million of SunFirst Bank's assets.

The failure of Mid City Bank is expected to cost the deposit insurance fund $12.7 million; that of SunFirst Bank is expected to cost $49.7 million.

Mid City Bank was the first bank in Nebraska to fail since June 2010; SunFirst Bank was the first Utah lender to be shuttered since March 2010. Failures have been concentrated in California, Florida, Georgia and Illinois.

In all of 2010, regulators seized 157 banks, the most in any year since the savings and loan crisis two decades ago. Those failures cost around $23 billion. The FDIC has said 2010 likely was the high-water mark for bank failures from the Great Recession.

In 2009, there were 140 bank failures that cost the insurance fund about $36 billion, a higher price tag than in 2010 because the banks involved were bigger on average. Twenty-five banks failed in 2008, the year the financial crisis struck with force; only three were closed in 2007.

From 2008 through 2010, bank failures cost the fund $76.8 billion. The FDIC expects failures from 2011 through 2015 to cost $19 billion.

The deposit insurance fund fell into the red in 2009. With failures slowing, the FDIC's fund balance turned positive in the second quarter of this year; it stood at $3.9 billion as of June 30.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-11-04-Bank%20Closures/id-1208efd2b215473da66b6d60c5a0eb4c

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Girl, 3, eats leftovers for 2 days after mom dies (AP)

WELLINGTON, New Zealand ? A 3-year-old girl comforted herself with her favorite toy and ate cheese, leftover lasagna and milk for two days after her mother died unexpectedly in their New Zealand home.

The girl's uncle, Pete Silbery, told The Associated Press on Friday that Shylah Silbery managed to open the fridge and comfort herself with a teddy bear named "Possum" after Lauren Silbery, 28, died.

The family last spoke to Lauren Silbery on Oct. 19, he said. Two days later, they were worried enough to call a friend who lived near her Wellington home. The friend could see the girl inside the home, but not the mother, prompting the family to call police, Pete Silbery said.

Police coaxed Shylah to drag a coffee table to the door so she could reach the lock and unlock the door, before she told them, "Mummy won't wake up," Silbery said.

"I can only imagine her in there for that long, trying to wake Mum up as well," he said.

Shylah spent several days in a hospital recovering from dehydration and diaper rash.

"She's doing OK now. She's still bubbly," he said. "When we lowered the coffin into the grave at the cemetery, though, she pointed at it and said 'Mummy's in there.' It was pretty heartbreaking."

Authorities are awaiting the results of an autopsy but don't believe Lauren Silbery's death was suspicious, Wellington police spokesman Victoria Davis said.

Source: http://us.rd.yahoo.com/dailynews/rss/oceania/*http%3A//news.yahoo.com/s/ap/20111104/ap_on_re_as/as_new_zealand_girl_survives

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Glowing Slap Bracelets Now Focus on Safety Over Fashion [Led]

What originally made slap bracelets a novelty in the early 90s, now makes them an easy to use safety accessory with the addition of a few glowing LEDs and some reflective fabrics. More »


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Sabre-toothed squirrel scurried at dinosaurs' feet

Truth is sometimes just as strange as fiction. Palaeontologists have unearthed fossils of a bizarre mammal that lived in the shadow of the dinosaurs and was a dead ringer for the sabre-toothed squirrel star of the computer-animated Ice Age films.

Mammals were a fixture of the dinosaur era, but their remains are rarely preserved. The new fossil, which comes from 95-million-year-old rocks in Argentina, is a tantalising sign of what we are missing. Its 2-centimetre-long skull has large eye sockets, a narrow snout and a formidable pair of long canines unlike anything seen before in Mesozoic mammals.

At the time this creature, dubbed Cronopio, roamed Earth, the marsupial and placental mammals that dominate today had already begun to branch out. But Cronopio was a more primitive beast. Its discovery confirms that early mammals tried out body shapes for which no living parallel exists, says Guillermo Rougier at the University of Louisville in Kentucky, whose team made the find.

Cronopio was dug out of rocks rich in the remains of giant sauropod and theropod dinosaurs. Its large eye sockets indicate it was possibly nocturnal, says Christian de Muizon at the Museum of Natural History in Paris, France, who was not a member of Rougier's team. "The function of the long canines is difficult to assess," says Rougier. "There is no real modern model for that."

The shape of the squirrel's molars suggests that it may have had a taste for insects, he adds. Rougier named the fossil after fictional characters in the novels of Argentinian writer Julio Cort?zar, but he is well aware of its silver screen doppelg?nger. "Some ridiculous-looking cartoon characters can sometimes be found later as real fossils," he says.

Journal reference: Nature, DOI: 10.1038/nature10591

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An app for all seasons and the best mobile offerings of October (Appolicious)

While there are hundreds of mobile applications that can tell you what the weather is like, our favorite app of October informs users of what to wear under any conditions. Other great new releases for the iPhone, iPad and Android devices include an addictive scribbling game which invites players to literally draw or write in features to solve puzzles, an app from a classic comic book publisher, and a library of interviews with some of the most acclaimed leaders in business and finance.

swackett (iPhone, iPod Touch Free)

As the leaves change and we inch towards winter, weather patterns are becoming less predictable. How in the world can we figure out what to wear on any given day. Sure, apps like The Weather Channel can provide a comprehensive forecast, but they don?t exactly tell you whether it?s wise to wear a hoodie or bring that scarf with you to the office. Enter swackett, the free app that not only tells you what it?s like outside, but also gives you a visual cue of what to bring out with you. Great for users doing a final check before rushing out the front door, swackett also includes information on humidity, dew point and wind conditions. Users who want to bypass advertising can also download a premium version of swackett for 99 cents.

Scribblenauts Remix (iPhone, iPod Touch, iPad $4.99)

Let your inspiration flow with this popular puzzle game that recently became available to the iPhone, iPad and iPod Touch. The Scribblenauts series, which was originally developed for the Nintendo DS, translates well to touchscreen devices. Players help the main character Maxwell solve puzzles by drawing or typing in tools like blocks or bridges to help them get from one frame to the next. Scribblenauts has 40 levels to tap into. Start playing the game from home on your iPad and continue after you leave the house on your iPhone without having to reset the game. Seems worthy of a smiley face scribble to me!

Marvel Comics (iPhone, iPod Touch, iPad, Android Free)

Although the free Marvel Comics app has long been available to owners of Apple?s iOS devices, Android users had to wait until now to access what is arguably the best comic book collection available. It?s worth the wait. Available for Android smartphones and tablet computers, Marvel Comics has a great collection of titles suitable for children and adults alike including Iron Man, Thor, Captain America and Spider-Man. The panel-by-panel view feature of the app really showcases the beautiful illustrations of the comics. Note, while many older and classic titles are available for free, newer comics are downloaded separately mostly for 99 cents a pop.

Adobe Reader (iPhone, iPod Touch, iPad, Android Free)

Because of competitive issues between Apple and Adobe, it is difficult for users to view content published on Adobe?s Flash-based file type on any iDevice. This new free app lets users access, read and print PDFs easily. It is a must have if your company shares information via PDF and/or if you enjoy downloading printable restaurant menus from the web. Not surprisingly, Adobe Reader applications have long been available on Android and other mobile platforms.

Bloomberg TV+ (iPad Free)

For decades, Bloomberg has published some of the most valuable and interesting business and finance news on the planet. Thanks to the free Bloomberg TV+ app, users will be able to access a lot of this world-class content all in one place. The app provides around-the-clock access to Bloomberg TV, including on-demand downloads of popular programing like the Charlie Rose show. Bloomberg in October also released free Radio+ apps for the iPhone and iPod Touch.

Have questions or comments about a mobile app? Contact Brad Spirrison at brad@appolicious.com, or visit www.appolicious.com and www.androidapps.com to learn more.

Source: http://us.rd.yahoo.com/dailynews/rss/applecomputer/*http%3A//us.rd.yahoo.com/dailynews/external/appolicious_rss/rss_appolicious_tc/http___www_appolicious_com_articles10084_an_app_for_all_seasons_and_the_best_mobile_offerings_of_october/43464231/SIG=13gj0atb1/*http%3A//www.appolicious.com/tech/articles/10084-an-app-for-all-seasons-and-the-best-mobile-offerings-of-october

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